Sequence analysis of the Staphylococcus aureus srrAB loci reveals that truncation of srrA affects growth and virulence factor expression.

نویسندگان

  • Alexa A Pragman
  • Lisa Herron-Olson
  • Laura C Case
  • Sara M Vetter
  • Evan E Henke
  • Vivek Kapur
  • Patrick M Schlievert
چکیده

The SrrAB system regulates metabolism and virulence factors in Staphylococcus aureus. We sequenced the srrAB loci of 21 isolates and performed a phylogenetic analysis. Vaginal and bovine isolates clustered together, while skin isolates were genetically diverse. Few nucleotide polymorphisms were observed, and most were synonymous. Two strains (N2 and N19) with N-terminal truncations in SrrA displayed defects in growth and abnormally upregulated virulence factor expression under low-oxygen conditions.

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عنوان ژورنال:
  • Journal of bacteriology

دوره 189 20  شماره 

صفحات  -

تاریخ انتشار 2007